Magnesium Alloys for Open-Pored Bioresorbable Implants

authored by: Hans Jürgen Maier, Stefan Julmi, Sabine Behrens, Christian Klose, Ann Kathrin Gartzke, Peter Wriggers, Anja Christina Waselau, Andrea Meyer-Lindenberg
Abstract: If bone defects occur, the body’s own healing mechanism can close them below a critical size; for larger defects, bone autografts are used. These are typically cut from the same person’s hip in a second surgery. Consequently, the risk of complications, such as inflammations, rises. To avoid the risks resulting from the second surgery, absorbable, open-pored implants can be used. In the present study, the suitability of different magnesium alloys as absorbable porous bone substitute material has been investigated. Using the investment casting process with its design flexibility, the implant’s structure can be adapted to the ideal pore geometry with respect to bone ingrowth behavior. Different magnesium alloys (Mg-La2, LAE442, and ZX61) were studied and rated in terms of their degradation rate, bone ingrowth behavior, biocompatibility, and resorbability of the individual alloying elements.
Organisation(s): Institute of Materials Science
Institute of Continuum Mechanics
External Organisation(s): Ludwig-Maximilians-Universität München (LMU)
Type: Article
Journal: JOM
Volume: 72
Pages: 1859-1869
No. of pages: 11
ISSN: 1047-4838
Publication date: 25.02.2020
Publication status: Published
Peer reviewed: Yes
ASJC Scopus subject areas: General Materials Science, General Engineering
Electronic version(s): https://doi.org/10.1007/s11837-020-04078-8 (Access: Open)
: Details in the research portal "Research@Leibniz University"

BibTeX

@article{a273e8347d65422da2a59cee5866c505,
title = "Magnesium Alloys for Open-Pored Bioresorbable Implants",
abstract = "If bone defects occur, the body{\textquoteright}s own healing mechanism can close them below a critical size; for larger defects, bone autografts are used. These are typically cut from the same person{\textquoteright}s hip in a second surgery. Consequently, the risk of complications, such as inflammations, rises. To avoid the risks resulting from the second surgery, absorbable, open-pored implants can be used. In the present study, the suitability of different magnesium alloys as absorbable porous bone substitute material has been investigated. Using the investment casting process with its design flexibility, the implant{\textquoteright}s structure can be adapted to the ideal pore geometry with respect to bone ingrowth behavior. Different magnesium alloys (Mg-La2, LAE442, and ZX61) were studied and rated in terms of their degradation rate, bone ingrowth behavior, biocompatibility, and resorbability of the individual alloying elements.",
author = "Maier, {Hans J{\"u}rgen} and Stefan Julmi and Sabine Behrens and Christian Klose and Gartzke, {Ann Kathrin} and Peter Wriggers and Waselau, {Anja Christina} and Andrea Meyer-Lindenberg",
note = "Funding information: Open Access funding provided by Projekt DEAL. Financial supported by the German Research Foundation (DFG) within the project “Interfacial effects and ingrowing behavior of magnesium-based foams as bioresorbable bone substitute material” (Grant No. 271761343) is gratefully acknowledged. The Xradia 520 Versa used in this study was also funded by the DFG (Grant No. 316923185).",
year = "2020",
month = feb,
day = "25",
doi = "10.1007/s11837-020-04078-8",
language = "English",
volume = "72",
pages = "1859--1869",
journal = "JOM",
issn = "1047-4838",
publisher = "Minerals, Metals and Materials Society",
number = "5",
}