A chemo-mechano-biological formulation for the effects of biochemical alterations on arterial mechanics

the role of molecular transport and multiscale tissue remodelling

authored by: Michele Marino, Giuseppe Pontrelli, Giuseppe Vairo, Peter Wriggers
Abstract: This paper presents a chemo-mechano-biological framework for arterial physiopathology. The model accounts for the fine remodelling in the multiscale hierarchical arrangement of tissue constituents and for the diffusion of molecular species involved in cell-cell signalling pathways. Effects in terms of alterations in arterial compliance are obtained.Asimple instructive example is introduced. Although oversimplified with respect to realistic case studies, the proposed application mimics the biochemical activity of matrix metalloproteinases, transforming growth factors beta and interleukins on tissue remodelling. Effects of macrophage infiltration, of intimal thickening and of a healing phase are investigated, highlighting the corresponding influence on arterial compliance. The obtained results show that the present approach is able to capture changes in arterial mechanics as a consequence of the alterations in tissue biochemical environment and cellular activity, as well as to incorporate the protective role of both autoimmune responses and pharmacological treatments.
Organisation(s): Institute of Continuum Mechanics
External Organisation(s): National Research Council Italy (CNR)
Tor Vergata University of Rome
Type: Article
Journal: Journal of the Royal Society Interface
Volume: 14
ISSN: 1742-5689
Publication date: 08.11.2017
Publication status: Published
Peer reviewed: Yes
ASJC Scopus subject areas: Biotechnology, Biophysics, Bioengineering, Biomaterials, Biochemistry, Biomedical Engineering
Electronic version(s): https://doi.org/10.1098/rsif.2017.0615 (Access: Open)
: Details in the research portal "Research@Leibniz University"

BibTeX

@article{6f01319dd2254c739d383e52893329e2,
title = "A chemo-mechano-biological formulation for the effects of biochemical alterations on arterial mechanics: the role of molecular transport and multiscale tissue remodelling",
abstract = "This paper presents a chemo-mechano-biological framework for arterial physiopathology. The model accounts for the fine remodelling in the multiscale hierarchical arrangement of tissue constituents and for the diffusion of molecular species involved in cell-cell signalling pathways. Effects in terms of alterations in arterial compliance are obtained.Asimple instructive example is introduced. Although oversimplified with respect to realistic case studies, the proposed application mimics the biochemical activity of matrix metalloproteinases, transforming growth factors beta and interleukins on tissue remodelling. Effects of macrophage infiltration, of intimal thickening and of a healing phase are investigated, highlighting the corresponding influence on arterial compliance. The obtained results show that the present approach is able to capture changes in arterial mechanics as a consequence of the alterations in tissue biochemical environment and cellular activity, as well as to incorporate the protective role of both autoimmune responses and pharmacological treatments.",
author = "Michele Marino and Giuseppe Pontrelli and Giuseppe Vairo and Peter Wriggers",
year = "2017",
month = nov,
day = "8",
doi = "10.1098/rsif.2017.0615",
language = "English",
volume = "14",
journal = "Journal of the Royal Society Interface",
issn = "1742-5689",
publisher = "The Royal Society",
number = "136",
}