Coupling Microscale Transport and Tissue Mechanics
Modeling Strategies for Arterial Multiphysics
- authored by
- M. Marino, G. Pontrelli, G. Vairo, P. Wriggers
- Abstract
Arterial physiopathological behavior involves multiphysics mechanisms, as the result of the complex interplay between microscale transport phenomena and mechanical equilibrium. This chapter draws a modeling strategy for coupling macroscopic mechanics and molecular diffusive/reactive mechanisms via biochemically-motivated tissue remodeling laws.Results have been obtained by addressing the effects of extracellular matrix remodeling driven by matrix metalloproteinases, transforming growth factor-beta and interleukines on the compliance of an axisymmetric arterial segment. Remarkably, obtained results show that the present approach is able to capture arterial dilation as a consequence of alterations in the cellular activity, as well as to incorporate the protective role of pharmacological treatments.
- Organisation(s)
-
Institute of Continuum Mechanics
- External Organisation(s)
-
National Research Council Italy (CNR)
Tor Vergata University of Rome
- Type
- Contribution to book/anthology
- Pages
- 77-112
- No. of pages
- 36
- Publication date
- 06.01.2017
- Publication status
- Published
- Peer reviewed
- Yes
- ASJC Scopus subject areas
- General Agricultural and Biological Sciences, General Biochemistry,Genetics and Molecular Biology
- Electronic version(s)
-
https://doi.org/10.1016/b978-0-12-804595-4.00004-3 (Access:
Closed)
-
Details in the research portal "Research@Leibniz University"