Geometric adaption of resorbable myocardial stabilizing structures based on the magnesium alloys LA63 and ZEK100 for the support of myocardial grafts on the left ventricle

authored by: M. Bauer, T. Hassel, C. H. Biskup, D. Hartung, T. Schilling, M. Weidling, P. Wriggers, F. Wacker, F. W. Bach, A. Haverich
Abstract: Damage of the heart muscle's tissue is irreversible due to the inability of adult cardiomyocytes to proliferate. Biological grafts like vascularized bowel segments are a novel approach to overcome these limitations. We found cardiac muscle cells within the heterotopically used gastric tissue in previous studies [1]. This may indicate an in vivo remodeling process. Unfortunately, early after transplantation the biological tissue does not exhibit sufficient mechanical strength to withstand high systolic pressures in the left ventricle (up to 240 mm Hg). Therefore, a stabilizing structure based on the bioresorbable magnesium alloys is needed for the support of the tissue until its physiologic remodeling. It is hypothesized that preformed structures adapted to the specific geometry of the targeted myocardial area are less likely to fracture during implantation or shortly after. In order to preform the structure, common areas of lesioned myocardium after infarction have been characterized by magnetic resonance imaging (MRI). Hereafter, the plane structures could be virtually preformed and the expected stresses were simulated with the finite elements method (FEM). This allows reduction of costs and time for developing new structures. Subsequently, structures of the magnesium alloys LA63 and ZEK100 were manufactured by abrasive water injection jet cutting (AWIJ), and preformed on the basis of the MRI data. Finally, the performance of preformed and non-preformed structures of different alloys was tested in an in-vitro testing rig.
Organisation(s): Institute of Materials Science
Institute of Continuum Mechanics
External Organisation(s): Hannover Medical School (MHH)
Type: Article
Journal: Biomedizinische Technik
Volume: 57
Pages: 22-25
No. of pages: 4
ISSN: 0013-5585
Publication date: 06.09.2012
Publication status: Published
Peer reviewed: Yes
ASJC Scopus subject areas: Biomedical Engineering
Electronic version(s): https://doi.org/10.1515/bmt-2012-4214 (Access: Open)
: Details in the research portal "Research@Leibniz University"

BibTeX

@article{058eef76c8e14a608faeb31a277e39eb,
title = "Geometric adaption of resorbable myocardial stabilizing structures based on the magnesium alloys LA63 and ZEK100 for the support of myocardial grafts on the left ventricle",
abstract = "Damage of the heart muscle's tissue is irreversible due to the inability of adult cardiomyocytes to proliferate. Biological grafts like vascularized bowel segments are a novel approach to overcome these limitations. We found cardiac muscle cells within the heterotopically used gastric tissue in previous studies [1]. This may indicate an in vivo remodeling process. Unfortunately, early after transplantation the biological tissue does not exhibit sufficient mechanical strength to withstand high systolic pressures in the left ventricle (up to 240 mm Hg). Therefore, a stabilizing structure based on the bioresorbable magnesium alloys is needed for the support of the tissue until its physiologic remodeling. It is hypothesized that preformed structures adapted to the specific geometry of the targeted myocardial area are less likely to fracture during implantation or shortly after. In order to preform the structure, common areas of lesioned myocardium after infarction have been characterized by magnetic resonance imaging (MRI). Hereafter, the plane structures could be virtually preformed and the expected stresses were simulated with the finite elements method (FEM). This allows reduction of costs and time for developing new structures. Subsequently, structures of the magnesium alloys LA63 and ZEK100 were manufactured by abrasive water injection jet cutting (AWIJ), and preformed on the basis of the MRI data. Finally, the performance of preformed and non-preformed structures of different alloys was tested in an in-vitro testing rig.",
author = "M. Bauer and T. Hassel and Biskup, {C. H.} and D. Hartung and T. Schilling and M. Weidling and P. Wriggers and F. Wacker and Bach, {F. W.} and A. Haverich",
note = "Funding information: The results presented here were acquired within the framework of the collaborative research centre 599 financed by the German Research Foundation (DFG). The authors would like to thank the DFG for their support.",
year = "2012",
month = sep,
day = "6",
doi = "10.1515/bmt-2012-4214",
language = "English",
volume = "57",
pages = "22--25",
journal = "Biomedizinische Technik",
issn = "0013-5585",
publisher = "Walter de Gruyter GmbH",
number = "SUPPL. 1 TRACK-S",
}