Degradation behaviour of LAE442-based plate-screw-systems in an in vitro bone model

verfasst von: Leonie Wolters, Silke Besdo, Nina Angrisani, Peter Wriggers, Britta Hering, Jan Marten Seitz, Janin Reifenrath
Abstract: The use of absorbable implant materials for fixation after bone fracture helps to avoid a second surgery for implant removal and the risks and costs involved. Magnesium (Mg) is well known as a potential metallic material for degradable implants. The aim of the present in vitro study was to evaluate if degradable LAE442-based magnesium plate-screw-systems are suitable candidates for osteosynthesis implants in load-bearing bones. The corrosion behaviour was tested concerning the influence of different surface treatments, coatings and screw torques. Steel plates and screws of the same size served as control. Plates without special treatment screwed on up to a specified torque of 15 cNm or 7 cNm, NaOH treated plates (15 cNm), magnesium fluoride coated plates (15 cNm) and steel plates as control (15 cNm) were examined in pH-buffered, temperature-controlled SBF solution for two weeks. The experimental results indicate that the LAE442 plates and screws coated with magnesium fluoride revealed a lower hydrogen evolution in SBF solution as well as a lower weight loss and volume decrease in μ-computed tomography (μCT). The nanoindentation and SEM/EDX measurements at several plate areas showed no significant differences. Summarized, the different screw torques did not affect the corrosion behaviour differently. Also the NaOH treatment seemed to have no essential influence on the degradation kinetics. The plates coated with magnesium fluoride showed a decreased corrosion rate. Hence, it is recommended to consider this coating for the next in vivo study.
Organisationseinheit(en): Institut für Kontinuumsmechanik
Institut für Fertigungstechnik und Werkzeugmaschinen
Externe Organisation(en): Stiftung Tierärztliche Hochschule Hannover
Typ: Artikel
Journal: Materials Science and Engineering C
Band: 49
Seiten: 305-315
Anzahl der Seiten: 11
ISSN: 0928-4931
Publikationsdatum: 07.01.2015
Publikationsstatus: Veröffentlicht
Peer-reviewed: Ja
ASJC Scopus Sachgebiete: Werkstoffwissenschaften (insg.), Physik der kondensierten Materie, Werkstoffmechanik, Maschinenbau
Elektronische Version(en): https://doi.org/10.1016/j.msec.2015.01.019 (Zugang: Geschlossen)
: Details im Forschungsportal „Research@Leibniz University“

BibTeX

@article{fd137fab3fea43c4a7a17a3e2a3bc26a,
title = "Degradation behaviour of LAE442-based plate-screw-systems in an in vitro bone model",
abstract = "The use of absorbable implant materials for fixation after bone fracture helps to avoid a second surgery for implant removal and the risks and costs involved. Magnesium (Mg) is well known as a potential metallic material for degradable implants. The aim of the present in vitro study was to evaluate if degradable LAE442-based magnesium plate-screw-systems are suitable candidates for osteosynthesis implants in load-bearing bones. The corrosion behaviour was tested concerning the influence of different surface treatments, coatings and screw torques. Steel plates and screws of the same size served as control. Plates without special treatment screwed on up to a specified torque of 15 cNm or 7 cNm, NaOH treated plates (15 cNm), magnesium fluoride coated plates (15 cNm) and steel plates as control (15 cNm) were examined in pH-buffered, temperature-controlled SBF solution for two weeks. The experimental results indicate that the LAE442 plates and screws coated with magnesium fluoride revealed a lower hydrogen evolution in SBF solution as well as a lower weight loss and volume decrease in μ-computed tomography (μCT). The nanoindentation and SEM/EDX measurements at several plate areas showed no significant differences. Summarized, the different screw torques did not affect the corrosion behaviour differently. Also the NaOH treatment seemed to have no essential influence on the degradation kinetics. The plates coated with magnesium fluoride showed a decreased corrosion rate. Hence, it is recommended to consider this coating for the next in vivo study.",
keywords = "Degradation, In vitro, Magnesium alloy, Nanoindentation, Plate-screw-system, μCT",
author = "Leonie Wolters and Silke Besdo and Nina Angrisani and Peter Wriggers and Britta Hering and Seitz, {Jan Marten} and Janin Reifenrath",
note = "Funding information: The authors gratefully acknowledge the financial support given by the German Research Foundation (DFG, SFB599/3) within the collaborative research project SFB 599. For excellent technical support we thank Anja Krabbenh{\"o}ft and Gian Luigi Angrisani.",
year = "2015",
month = jan,
day = "7",
doi = "10.1016/j.msec.2015.01.019",
language = "English",
volume = "49",
pages = "305--315",
journal = "Materials Science and Engineering C",
issn = "0928-4931",
publisher = "Elsevier BV",
}