Development of Magnesium Alloy Scaffolds to Support Biological Myocardial Grafts
A Finite Element Investigation
- verfasst von
- Martin Weidling, Silke Besdo, Tobias Schilling, Michael Bauer, Thomas Hassel, Friedrich Wilhelm Bach, Hans Jürgen Maier, Jacques Lamon, Axel Haverich, Peter Wriggers
- Abstract
Lesioned myocardial tissue can be replaced with innovative biological grafts. However, the strength of most biological grafts is initially not sufficient for left ventricular applications. Implants that mechanically support these grafts and gradually lose their function as the graft develops its strength are a possible solution. We are developing magnesium alloy scaffolds for this purpose. The finite element method was used to perform simulations wherein scaffolds are deformed according to the heart movement. This allows us to identify highly stressed regions within the implant that need design changes. Preformed scaffolds were determined to have significantly lower stresses in comparison to flat ones. The method of tensile triangles suggests shape changes for notable stress reduction. Furthermore, new scaffold shapes were developed and simulated. Two of them are recommended for further examinations through in vitro and in vivo tests. A completely new alternative scaffold concept is also proposed.
- Organisationseinheit(en)
-
Institut für Werkstoffkunde
Institut für Kontinuumsmechanik
- Externe Organisation(en)
-
Medizinische Hochschule Hannover (MHH)
Universite Paris 6
- Typ
- Artikel
- Journal
- Lecture Notes in Applied and Computational Mechanics
- Band
- 74
- Seiten
- 81-100
- Anzahl der Seiten
- 20
- ISSN
- 1613-7736
- Publikationsdatum
- 01.01.2015
- Publikationsstatus
- Veröffentlicht
- Peer-reviewed
- Ja
- ASJC Scopus Sachgebiete
- Maschinenbau, Theoretische Informatik und Mathematik
- Elektronische Version(en)
-
https://doi.org/10.1007/978-3-319-10981-7_6 (Zugang:
Geschlossen)
