Characterization and modeling of additively manufactured Ti-6Al-4V alloy with modified surfaces for medical applicationsProvisionally accepted

verfasst von: Hüray Ilayda Kök, Tonya Andreeva, Sebastian Stammkötter, Cindy Reinholdt, Osman Akbas, Anne Maren Jahn, Florian Gamon, Sandra Fuest, Mirko Teschke, Mirijam Schäfer, Michael Müller, Alexander Koch, Ole Jung, Mike Barbeck, Andreas Greuling, Ralf Smeets, Jörg Hermsdorf, Rumen Krastev, Philipp Junker, Meike Stiesch, Frank Walther
Abstract: In the field of biomedical implants, additively manufactured titanium alloys, particularly Ti-6Al-4V, hold significant potential due to their biocompatibility and mechanical properties. This study focuses on the characterization and modeling of additively manufactured Ti-6Al-4V alloy for dental and maxillofacial implants, emphasizing fatigue behavior, surface modification, and their combined effects on cyto-and osseocompatibility. Experimental methods, including tensile, compression, and fatigue testing, were applied alongside in-silico simulations to assess the long-term mechanical performance of the material. Surface properties were further modified through sandblasting and coating techniques to enhance cell adhesion and proliferation. By using in-vitro methods, the cytocompatibility of the coatings and materials was examined followed by in-vivo tests to determine osseocompatibility. Results demonstrated that appropriate surface roughness and modifications are essential in optimizing osseointegration, while the layer-by-layer additive manufacturing process influenced the fatigue life and stability. These findings contribute to the development of patient-specific implants, optimizing both mechanical integrity and biological integration for enhanced clinical outcomes. This work summarizes the investigations on additively manufactured Ti-6Al-4V alloy of the research unit 5250 "Mechanism-based characterization and modeling of permanent and bioresorbable implants with tailored functionality based on innovative in vivo, in vitro and in silico methods" funded by the Germany Research Foundation (DFG).
Organisationseinheit(en): Institut für Kontinuumsmechanik
Externe Organisation(en): Hochschule Reutlingen
Technische Universität Dortmund
Universitätsmedizin Rostock
Medizinische Hochschule Hannover (MHH)
Laser Zentrum Hannover e.V. (LZH)
Universitätsklinikum Hamburg-Eppendorf
Typ: Artikel
Journal: Frontiers in Bioengineering and Biotechnology
Band: 13
ISSN: 2296-4185
Publikationsdatum: 24.02.2025
Publikationsstatus: Angenommen/Im Druck
Peer-reviewed: Ja
Elektronische Version(en): https://doi.org/10.3389/fbioe.2025.1526873 (Zugang: Offen)
: Details im Forschungsportal „Research@Leibniz University“

BibTeX

@article{144a2716fe3241fcaf1dc3e807be5717,
title = "Characterization and modeling of additively manufactured Ti-6Al-4V alloy with modified surfaces for medical applicationsProvisionally accepted",
abstract = "In the field of biomedical implants, additively manufactured titanium alloys, particularly Ti-6Al-4V, hold significant potential due to their biocompatibility and mechanical properties. This study focuses on the characterization and modeling of additively manufactured Ti-6Al-4V alloy for dental and maxillofacial implants, emphasizing fatigue behavior, surface modification, and their combined effects on cyto-and osseocompatibility. Experimental methods, including tensile, compression, and fatigue testing, were applied alongside in-silico simulations to assess the long-term mechanical performance of the material. Surface properties were further modified through sandblasting and coating techniques to enhance cell adhesion and proliferation. By using in-vitro methods, the cytocompatibility of the coatings and materials was examined followed by in-vivo tests to determine osseocompatibility. Results demonstrated that appropriate surface roughness and modifications are essential in optimizing osseointegration, while the layer-by-layer additive manufacturing process influenced the fatigue life and stability. These findings contribute to the development of patient-specific implants, optimizing both mechanical integrity and biological integration for enhanced clinical outcomes. This work summarizes the investigations on additively manufactured Ti-6Al-4V alloy of the research unit 5250 {"}Mechanism-based characterization and modeling of permanent and bioresorbable implants with tailored functionality based on innovative in vivo, in vitro and in silico methods{"} funded by the Germany Research Foundation (DFG).",
author = "K{\"o}k, {H{\"u}ray Ilayda} and Tonya Andreeva and Sebastian Stammk{\"o}tter and Cindy Reinholdt and Osman Akbas and Jahn, {Anne Maren} and Florian Gamon and Sandra Fuest and Mirko Teschke and Mirijam Sch{\"a}fer and Michael M{\"u}ller and Alexander Koch and Ole Jung and Mike Barbeck and Andreas Greuling and Ralf Smeets and J{\"o}rg Hermsdorf and Rumen Krastev and Philipp Junker and Meike Stiesch and Frank Walther",
note = "{\textcopyright} 2025 K{\"o}k, Andreeva, Stammk{\"o}tter, Reinholdt, Akbas, Jahn, Gamon, Fuest, Teschke, Sch{\"a}fer, Michael, Koch, Jung, Barbeck, Greuling, Smeets, Hermsdrof, Krastev, Junker, Stiesch and Walther",
year = "2025",
month = feb,
day = "24",
doi = "10.3389/fbioe.2025.1526873",
language = "English",
volume = "13",
journal = "Frontiers in Bioengineering and Biotechnology",
issn = "2296-4185",
publisher = "Frontiers Media S.A.",
}